�Pentoxifylline, a drug exploited to
do by patients with circulation problems, may too benefit those with
kidney disease caused by diabetes and other conditions. Specifically,
pentoxifylline decreases proteinuria, the abnormal leakage of protein
into the urine, according to two articles in the September issue of the
American Journal of Kidney Diseases, the
Tuesday, 2 September 2008
Wednesday, 13 August 2008
Enrollment In Phase IIb Clinical Trial For I-vation� TA (MK-0140) Suspended Pending Review Of Study Design By Merck & Co., Inc.
�SurModics, Inc. (Nasdaq: SRDX), a leading provider of surface alteration and dose delivery technologies to the healthcare diligence, announced that Merck & Co., Inc. has informed the fellowship that, in light of results reported in a recently published study comparison laser discussion and intravitreal injections of triamcinolone acetonide (TA) in patients with diabetic macular edema (DME), Merck is reevaluating the design of its Phase IIb clinical trial for I-vation� TA. Pending this review, Merck is suspending enrollment of new patients in the Phase IIb clinical test. The License and Research Collaboration Agreement with Merck continues, and other ongoing development programs with Merck are untouched.
Merck's Phase IIb clinical trial is intended to evaluate the safety and efficacy of SurModics' I-vation TA in patients with DME. The suspension of the clinical trial follows the publication of a study sponsored by the National Eye Institute suggesting a benefit for laser treatment over intravitreal injections of TA. This lately published reputation does non discuss I-vation TA, nor did the study value the safety or efficaciousness of free burning drug livery systems.
"The decision to suspend enrollment in this clinical tribulation is based solely on the results reported in a lately published study comparing laser treatment and intravitreal injections of TA," said Bruce Barclay, president and CEO of SurModics. "We believe the data from the Phase I and Phase IIb clinical trials generated to date provide support for the tolerability profile of I-vation TA, and more by and large, that of the I-vation sustained delivery platform."
Additionally, SurModics remains committed to its ongoing development programs with multiple other customers pursuing the development of products incorporating SurModics' sustained delivery technologies, including the I-vation chopine, for the treatment of diseases of the optic.
About SurModics, Inc.
SurModics, Inc. is a leading provider of surface qualifying and drug delivery technologies to the healthcare industry. SurModics partners with the world's foremost medical device, pharmaceutical and life science companies to develop and commercialize groundbreaking products that result in improved patient outcomes. Core offerings admit: drug livery technologies (coatings, microparticles, and implants); surface modification coating technologies that impart prurience, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. Collaborative efforts include a sustained dose delivery system in human trials for treatment of retinal disease and the drug delivery polymer matrix on the first-to-market drug-eluting coronary stent. SurModics is headquartered in Eden Prairie, Minnesota and its Brookwood Pharmaceuticals subsidiary company is set in Birmingham, Alabama. For more information about the company, natter http://www.surmodics.com. The content of SurModics' website is not part of this release or part of any filings the company makes with the SEC.
Safe Harbor for Forward-Looking Statements
This press departure contains innovative statements. Statements that are not historical or stream facts, including statements around beliefs and expectations, ar forward-looking statements. Forward-looking statements involve implicit in risks and uncertainties, and important factors could grounds actual results to differ materially from those hoped-for, including the following: (1) realizing the full potential difference benefits of the company's agreement with Merck & Co., Inc. requires the development of new products and applications of engineering, and the successful management of clinical trials and related extraneous and domestic regulatory processes; (2) costs or difficulties relating to the integration of the businesses of Brookwood Pharmaceuticals and BioFX Laboratories with SurModics' business organisation may be greater than expected and may adversely affect the company's results of operations and financial condition; (3) developments in the regulative environment, as well as market and economic conditions, and our reliance on third parties, may adversely affect our business trading operations and gainfulness, and the company's ability to reach our fiscal 2008 incorporated goals and to realise the voltage of our pipeline; and (4) former factors identified under "Risk Factors" in Part I, Item 1A of our Annual Report on Form 10-K for the financial year concluded September 30, 2007, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our web site at hypertext transfer protocol://www.surmodics.com and at the SEC web site at hypertext transfer protocol://www.securities and Exchange Commission.gov. Forward-looking statements talk only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.
SurModics, Inc.
More info
Merck's Phase IIb clinical trial is intended to evaluate the safety and efficacy of SurModics' I-vation TA in patients with DME. The suspension of the clinical trial follows the publication of a study sponsored by the National Eye Institute suggesting a benefit for laser treatment over intravitreal injections of TA. This lately published reputation does non discuss I-vation TA, nor did the study value the safety or efficaciousness of free burning drug livery systems.
"The decision to suspend enrollment in this clinical tribulation is based solely on the results reported in a lately published study comparing laser treatment and intravitreal injections of TA," said Bruce Barclay, president and CEO of SurModics. "We believe the data from the Phase I and Phase IIb clinical trials generated to date provide support for the tolerability profile of I-vation TA, and more by and large, that of the I-vation sustained delivery platform."
Additionally, SurModics remains committed to its ongoing development programs with multiple other customers pursuing the development of products incorporating SurModics' sustained delivery technologies, including the I-vation chopine, for the treatment of diseases of the optic.
About SurModics, Inc.
SurModics, Inc. is a leading provider of surface qualifying and drug delivery technologies to the healthcare industry. SurModics partners with the world's foremost medical device, pharmaceutical and life science companies to develop and commercialize groundbreaking products that result in improved patient outcomes. Core offerings admit: drug livery technologies (coatings, microparticles, and implants); surface modification coating technologies that impart prurience, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. Collaborative efforts include a sustained dose delivery system in human trials for treatment of retinal disease and the drug delivery polymer matrix on the first-to-market drug-eluting coronary stent. SurModics is headquartered in Eden Prairie, Minnesota and its Brookwood Pharmaceuticals subsidiary company is set in Birmingham, Alabama. For more information about the company, natter http://www.surmodics.com. The content of SurModics' website is not part of this release or part of any filings the company makes with the SEC.
Safe Harbor for Forward-Looking Statements
This press departure contains innovative statements. Statements that are not historical or stream facts, including statements around beliefs and expectations, ar forward-looking statements. Forward-looking statements involve implicit in risks and uncertainties, and important factors could grounds actual results to differ materially from those hoped-for, including the following: (1) realizing the full potential difference benefits of the company's agreement with Merck & Co., Inc. requires the development of new products and applications of engineering, and the successful management of clinical trials and related extraneous and domestic regulatory processes; (2) costs or difficulties relating to the integration of the businesses of Brookwood Pharmaceuticals and BioFX Laboratories with SurModics' business organisation may be greater than expected and may adversely affect the company's results of operations and financial condition; (3) developments in the regulative environment, as well as market and economic conditions, and our reliance on third parties, may adversely affect our business trading operations and gainfulness, and the company's ability to reach our fiscal 2008 incorporated goals and to realise the voltage of our pipeline; and (4) former factors identified under "Risk Factors" in Part I, Item 1A of our Annual Report on Form 10-K for the financial year concluded September 30, 2007, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our web site at hypertext transfer protocol://www.surmodics.com and at the SEC web site at hypertext transfer protocol://www.securities and Exchange Commission.gov. Forward-looking statements talk only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.
SurModics, Inc.
More info
Wednesday, 6 August 2008
Hey, Jonas Brothers Fans: The Jersey Boys' 3-D Flick Has A Release Date!
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Jonas Brothers 3-D Concert Flick Gets A Release Date
Published by Brian Jacks on Friday, August 1, 2008 at 2:14 pm.
You�ve been bombarding TRL, spamming our web site and screaming on FNMTV. Now you�ll be capable to get up, shut and personal with the Jersey boys themselves. According to Variety, the Jonas Brothers� previously announced 3-D concert moving-picture show has snagged a release date: February 27, 2009.
The currently ungentle Disney flick will come after the mold of the recent Miley Cyrus smash hit, combining live concert footage with behind-the-scenes moments. Not much else is known about the flick yet, simply stay tuned to the MTV Movies Blog for all your breaking Jonas Brothers picture needs.
So how excited are you guys to see the Jonas Brothers in glorious 3-D? Are you already clearing your schedules to see it possibility day? Chime in below!
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Thursday, 26 June 2008
Nude challenge in Big Brother house
New housemate Stuart has set pulses racing yet again in the 'Big Brother' house with the latest task.
Having flirted with both Sylvia and Jennifer, the 25-year-old was called to the Diary Room to find out about the challenge.
On returning he told the group: "Housemates must use their imagination and creativity as they take part in Big Brother's Life Class. Housemates must either paint or sculpt the new housemate, Stuart, in the nude."
Asked to explain her work, Sylvia said: "This is my sexy interpretation of Stu. I have focused on his sexy body with his beautiful pecs going on, his nice eyes and I think his face is really pretty."
But Stuart picked Jennifer - who said her painting was a reference to Adonis - as the winner.
There was further disappointment for Sylvia last night when Stuart appeared to play down the prospects of a relationship between them.
After talking to Stuart, Jennifer told Sylvia: "He's not saying that he doesn't find you attractive, and that he doesn't think things could develop in here. He's just saying that at such an early stage, after two days... he doesn't want to start anything and isolate himself from the group."
Having flirted with both Sylvia and Jennifer, the 25-year-old was called to the Diary Room to find out about the challenge.
On returning he told the group: "Housemates must use their imagination and creativity as they take part in Big Brother's Life Class. Housemates must either paint or sculpt the new housemate, Stuart, in the nude."
Asked to explain her work, Sylvia said: "This is my sexy interpretation of Stu. I have focused on his sexy body with his beautiful pecs going on, his nice eyes and I think his face is really pretty."
But Stuart picked Jennifer - who said her painting was a reference to Adonis - as the winner.
There was further disappointment for Sylvia last night when Stuart appeared to play down the prospects of a relationship between them.
After talking to Stuart, Jennifer told Sylvia: "He's not saying that he doesn't find you attractive, and that he doesn't think things could develop in here. He's just saying that at such an early stage, after two days... he doesn't want to start anything and isolate himself from the group."
Wednesday, 18 June 2008
Razorlight - Borrell Movie Stalled
RAZORLIGHT frontman JOHNNY BORRELL's acting career has been thrown into question - after production on his debut movie THE MEAT TRADE has stalled.
The British rocker was reportedly set to play a musician killed by two grave robbers - played by Colin Firth and Robert Carlyle - in novelist Irvine Welsh's latest screenplay, originally slated for release later this year (08).
But Borrell's big screen debut appears to still be some way off - the singer has revealed the project is still waiting for the green light.
He says, "It's still not certain yet. We'll just have to wait and see. But I'm really hoping that it does happen because I've read the script and it's brilliant - I get offers to act all the time, but this is the first one I've ever wanted to do."
See Also
Monday, 9 June 2008
Operator Please - Operator Please Keyboardist Quits
Australian rockers OPERATOR PLEASE have parted ways with their keyboardist SARAH GARDINER.
The band insist the split was mutual following Gardiner's two-month break from touring with the group.
Gardiner aired her intentions to leave Operator Please shortly after filming the video for their forthcoming single Two For My Seconds.
In a posting on social networking site Facebook, Gardiner writes, "The video features myself truly playing the piano on a busy street in Sydney - an oddly appropriate send off!"
Operator Please are currently auditioning replacements for their upcoming European tour, which kicks off in London on 18 April (08).
See Also
Tuesday, 3 June 2008
Corrie star Haworth expecting first child
'Coronation Street' star Julia Haworth has revealed that she is pregnant with her first child.
The actress, who plays Claire Peacock in the soap, is due to give birth in July.
The actress revealed she found out the news in November but wanted to keep it quiet until her 12 week scan.
She told The Mirror newspaper: "We haven't stopped smiling. It's such a special time and I feel so lucky we're going to share it."
Haworth added that her character's postnatal depression following the birth of son Freddie had helped "prepare" her for being a mother.
The 28-year-old married accountant Jon Wormold in May 2006 after a two-year romance.
The actress, who plays Claire Peacock in the soap, is due to give birth in July.
The actress revealed she found out the news in November but wanted to keep it quiet until her 12 week scan.
She told The Mirror newspaper: "We haven't stopped smiling. It's such a special time and I feel so lucky we're going to share it."
Haworth added that her character's postnatal depression following the birth of son Freddie had helped "prepare" her for being a mother.
The 28-year-old married accountant Jon Wormold in May 2006 after a two-year romance.
Tuesday, 27 May 2008
Papoose Dismisses 'Ridiculous' Remy Ma Escape-Plot Rumors, Promises Appeal And Wedding
With thoughts of injustice flowing through his mind, Papoose erupted in anger in a New York courtroom Tuesday after hearing that his fiancee, Remy Ma, had been sentenced to eight years in prison.
"I got a little bit aggravated. I think anybody would," Pap, wearing a wedding band on his ring finger, said in New York's Platinum Studios Wednesday. "To see a female get persecuted like that for something they didn't do. ... Then, on the other hand, you see Sean Bell get murdered by police and they just walk out the courtroom. A crime they admitted they did. Then somebody that's suspected of a crime goes to jail and gets sentenced to eight years. These police gun a man down and murder him. In the same city a mother gets snatched away from her child. It's aggravating."
Remy Ma (born Reminisce Smith) was sentenced after being convicted of shooting her onetime close friend Makeda Barnes-Joseph during a dispute over money. Smith claimed that Barnes-Joseph stole $3,000 from her.
"I never seen a case with more issues, more grounds for appeal than hers," said Pap, who called Remy's lawyer, Ivan Fisher, "incompetent." "Everybody had different stories. Nobody's stories matched. They all lied on the stand. It's disgusting. It's obvious what that case was about."
There's no doubt that Barnes-Joseph was shot. Fisher called it an accident. Papoose refused to go into detail about what he believes to be the truth surrounding the shooting, but he did say his fiancee would have a new lawyer during the appeal. He talked to Remy on Wednesday and said the message she has for the people, especially her fans, is "'Thanks for the support. Black people, go to jury [duty]." Papoose said, "Out of a hundred-and-something jurors while they were doing jury selection, there were only six blacks. ... It was an all-white jury. ... [But] she's maintaining. She's got a strong mind. The case is definitely gonna be appealed. Everything in the dark will come to the light."
Although Pap talks to Remy regularly, he cannot see her in person any time soon. Over the weekend, the two were to be married on Rikers Island. During his visit, however, there was supposedly some controversy over something on his key chain; reports circulated that Pap tried to sneak Remy a tiny skeleton key that can unlock handcuffs.
"That whole claim and that rumor is ridiculous," he said. "Ever since she's been incarcerated, I've been going to visit her consistently. I've always had my key chain that has the key to my truck, my crib. ... Everything that was on my key chain was always there [during my visits]. The [corrections officers have] always seen my key chain.
"This particular time, this one dude. I guess he had a bad day or something," Pap continued. "One C.O. looked at it like, 'You can't bring this in here.' "
Pap added that the corrections officer took the small key in question and let Pap go on about his business. Twenty-five minutes later, the Brooklyn MC was called in to speak to the warden.
"It was a small key," Pap said. "I honestly don't think the sh-- could open handcuffs. [Sneak it to her] on Rikers Island? What are you gonna do with that? For me to give her a handcuff key, that's ridiculous. They put in the papers [that] I was trying to help her escape and all that. If that was true, I would have been arrested. It was just an excuse for them to do some of the foul things they did.
"Everybody knows if it was a felony, I would have been arrested," he added.
At press time, officials for Rikers Island could not be reached for comment. Although Pap had to leave the prison and cannot return to see Remy in the foreseeable future, he maintains his ban will be lifted soon and that he and Rem will get married.
"People scatter. My heart is pure. It's not in my heart to leave somebody when they're in a time of need," he said of his devotion to Remy. "[Crisis] actually brings me closer to them. I'mma hold her down, keep her mind steady. She's gonna be alright."
The couple met a few years ago through Pap's musical mentor, DJ Kay Slay.
"She's sincere, she's got a good heart," Poose said. "We got a chance to build on a lot of situations. We've been through a couple of things, [and] I got a chance to see she had a good heart."
Papoose just finished a song called "My Girl" where he talks about Remy in one of the verses. "Why I need a handcuff key when I got the key to your heart?" he raps.
"It's about a daughter, mother and wife," he said. "It goes out to all the females in our lives that hold us down, keep us strong. They brought us into the world. We gotta return the favor."
See Also
Sunday, 18 May 2008
Anthony Pappa
Artist: Anthony Pappa
Genre(s):
Dance
Discography:
Global Underground: NuBreed, CD2
Year: 2000
Tracks: 13
Global Underground: NuBreed, CD1
Year: 2000
Tracks: 12
Though Susan B. Anthony Daddy had already made the rounds at many of England's big top clubs such as Renascence, Bat, Bedrock, and Ministry of Sound, it wasn't until he was awarded the come out volume in Global Underground's ambitious Nu Breed series that many rattle gave him a close seem. Always since he south Korean won Australia's D.M.C. DJ backup at the tender eld of 15, there has constantly been something special some Pop. Since those late-teen years DJing in Commonwealth of Australia, he left for the electronic euphony utopia of England, where he had hopes of decently 1 of the world's top of the inning DJs. By his ahead of time twenties, he was acknowledged as a gifted DJ and was spinning around the human race only never reached the elite group senior high school of truthful virtuoso position alongside the world's Sashas and St. Paul Van Dyks. With his own albums in both Rebirth and Orbicular Resistance's popular series of integrate CDs, he has come 1 stone's throw finisher to attaining his dream of becoming 1 of the world's genus Circus tent DJs. In 2001 Pappa was highlighted on Choo Choo Records' start loudness of integrate CDs.
Winehouse refused visa for Grammys
Winehouse refused visa for Grammys
Amy Winehouse will non be playacting at this year's Grammy Awards because her request for a visa has been turned down by the US Embassy in John Griffith Chaney, according to her publiciser.
The Exterior Organization, which counts the troubled retro-soul isaac Merrit Singer among its clients, said in a statement: "Amy has been progressing well since entrance a rehabilitation clinic deuce weeks ago and although disappointed with the decision has accepted the ruling and will be concentrating on her recovery."
The 24-year-old singer and her acclaimed 'Back to Black' album are nominated in six-spot categories for the Grammy Awards in Los Angeles on Sun.
Organisers of the music awards ar now arrangement for the singer to perform via satellite.
Since the album's US release last year, she has cancelled a curve of appearances amid reports of drug use.
Kidman to play exposed CIA Agent
Kidman to play exposed CIA Agent
Nicole Kidman is to work with 'The Bourn Identity' film director Doug Liman on a freshly dramatic event well-nigh the Central Intelligence Agency agent, Valerie Plame, whose identity was leaked after her diplomat married man questioned evidence used to justify the war in Al-Iraq.
Speech production to MTV about the film, Liman said: "I have a really, really insane take on how to secernate it. It's so outrageous."
He continued: "Ultimately, I'd be doing something no unity has of all time done earlier. Thus it's automatically appealing to me. I'm just starting to explore whether [what I'm preparation ] is even possible to do."
Kidman's freshly film, 'Margot at the Wedding', opens in Irish cinemas on Fri 28 February.
Benabar
Court now orders Spears psych exam
Court now orders Spears psych exam
A label has ruled that troubled pop star Britney Spears mustiness be examined by a court-appointed psychiatrist to set if she understands the legal proceedings involving her.
Reuters reports that Los Angeles Superior Royal court Commissioner Robert Falcon Scott Gordon ordered on Mon that the head-shrinker file a report on the 26-year-old's mental condition by 13 February.
On 14 February it will be decided how much yearner Spears' assets should rest under the temporary control of her church Father and his lawyer.
Commissioner Gordon too said that a restraining orderliness against Spears' self-styled handler and intimate, Surface-to-air missile Lutfi, forbids him from any sort of contact with her.
Spears was taken to the UCLA Medical Center for a 72-hour psychiatric rating last calendar week; her stay has now been extended to 2 weeks.
R. Kelly's lawyer wants trial secrecy
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