�Pentoxifylline, a drug exploited to
do by patients with circulation problems, may too benefit those with
kidney disease caused by diabetes and other conditions. Specifically,
pentoxifylline decreases proteinuria, the abnormal leakage of protein
into the urine, according to two articles in the September issue of the
American Journal of Kidney Diseases, the
Tuesday, 2 September 2008
Wednesday, 13 August 2008
Enrollment In Phase IIb Clinical Trial For I-vation� TA (MK-0140) Suspended Pending Review Of Study Design By Merck & Co., Inc.
�SurModics, Inc. (Nasdaq: SRDX), a leading provider of surface alteration and dose delivery technologies to the healthcare diligence, announced that Merck & Co., Inc. has informed the fellowship that, in light of results reported in a recently published study comparison laser discussion and intravitreal injections of triamcinolone acetonide (TA) in patients with diabetic macular edema (DME), Merck is reevaluating the design of its Phase IIb clinical trial for I-vation� TA. Pending this review, Merck is suspending enrollment of new patients in the Phase IIb clinical test. The License and Research Collaboration Agreement with Merck continues, and other ongoing development programs with Merck are untouched.
Merck's Phase IIb clinical trial is intended to evaluate the safety and efficacy of SurModics' I-vation TA in patients with DME. The suspension of the clinical trial follows the publication of a study sponsored by the National Eye Institute suggesting a benefit for laser treatment over intravitreal injections of TA. This lately published reputation does non discuss I-vation TA, nor did the study value the safety or efficaciousness of free burning drug livery systems.
"The decision to suspend enrollment in this clinical tribulation is based solely on the results reported in a lately published study comparing laser treatment and intravitreal injections of TA," said Bruce Barclay, president and CEO of SurModics. "We believe the data from the Phase I and Phase IIb clinical trials generated to date provide support for the tolerability profile of I-vation TA, and more by and large, that of the I-vation sustained delivery platform."
Additionally, SurModics remains committed to its ongoing development programs with multiple other customers pursuing the development of products incorporating SurModics' sustained delivery technologies, including the I-vation chopine, for the treatment of diseases of the optic.
About SurModics, Inc.
SurModics, Inc. is a leading provider of surface qualifying and drug delivery technologies to the healthcare industry. SurModics partners with the world's foremost medical device, pharmaceutical and life science companies to develop and commercialize groundbreaking products that result in improved patient outcomes. Core offerings admit: drug livery technologies (coatings, microparticles, and implants); surface modification coating technologies that impart prurience, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. Collaborative efforts include a sustained dose delivery system in human trials for treatment of retinal disease and the drug delivery polymer matrix on the first-to-market drug-eluting coronary stent. SurModics is headquartered in Eden Prairie, Minnesota and its Brookwood Pharmaceuticals subsidiary company is set in Birmingham, Alabama. For more information about the company, natter http://www.surmodics.com. The content of SurModics' website is not part of this release or part of any filings the company makes with the SEC.
Safe Harbor for Forward-Looking Statements
This press departure contains innovative statements. Statements that are not historical or stream facts, including statements around beliefs and expectations, ar forward-looking statements. Forward-looking statements involve implicit in risks and uncertainties, and important factors could grounds actual results to differ materially from those hoped-for, including the following: (1) realizing the full potential difference benefits of the company's agreement with Merck & Co., Inc. requires the development of new products and applications of engineering, and the successful management of clinical trials and related extraneous and domestic regulatory processes; (2) costs or difficulties relating to the integration of the businesses of Brookwood Pharmaceuticals and BioFX Laboratories with SurModics' business organisation may be greater than expected and may adversely affect the company's results of operations and financial condition; (3) developments in the regulative environment, as well as market and economic conditions, and our reliance on third parties, may adversely affect our business trading operations and gainfulness, and the company's ability to reach our fiscal 2008 incorporated goals and to realise the voltage of our pipeline; and (4) former factors identified under "Risk Factors" in Part I, Item 1A of our Annual Report on Form 10-K for the financial year concluded September 30, 2007, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our web site at hypertext transfer protocol://www.surmodics.com and at the SEC web site at hypertext transfer protocol://www.securities and Exchange Commission.gov. Forward-looking statements talk only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.
SurModics, Inc.
More info
Merck's Phase IIb clinical trial is intended to evaluate the safety and efficacy of SurModics' I-vation TA in patients with DME. The suspension of the clinical trial follows the publication of a study sponsored by the National Eye Institute suggesting a benefit for laser treatment over intravitreal injections of TA. This lately published reputation does non discuss I-vation TA, nor did the study value the safety or efficaciousness of free burning drug livery systems.
"The decision to suspend enrollment in this clinical tribulation is based solely on the results reported in a lately published study comparing laser treatment and intravitreal injections of TA," said Bruce Barclay, president and CEO of SurModics. "We believe the data from the Phase I and Phase IIb clinical trials generated to date provide support for the tolerability profile of I-vation TA, and more by and large, that of the I-vation sustained delivery platform."
Additionally, SurModics remains committed to its ongoing development programs with multiple other customers pursuing the development of products incorporating SurModics' sustained delivery technologies, including the I-vation chopine, for the treatment of diseases of the optic.
About SurModics, Inc.
SurModics, Inc. is a leading provider of surface qualifying and drug delivery technologies to the healthcare industry. SurModics partners with the world's foremost medical device, pharmaceutical and life science companies to develop and commercialize groundbreaking products that result in improved patient outcomes. Core offerings admit: drug livery technologies (coatings, microparticles, and implants); surface modification coating technologies that impart prurience, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. Collaborative efforts include a sustained dose delivery system in human trials for treatment of retinal disease and the drug delivery polymer matrix on the first-to-market drug-eluting coronary stent. SurModics is headquartered in Eden Prairie, Minnesota and its Brookwood Pharmaceuticals subsidiary company is set in Birmingham, Alabama. For more information about the company, natter http://www.surmodics.com. The content of SurModics' website is not part of this release or part of any filings the company makes with the SEC.
Safe Harbor for Forward-Looking Statements
This press departure contains innovative statements. Statements that are not historical or stream facts, including statements around beliefs and expectations, ar forward-looking statements. Forward-looking statements involve implicit in risks and uncertainties, and important factors could grounds actual results to differ materially from those hoped-for, including the following: (1) realizing the full potential difference benefits of the company's agreement with Merck & Co., Inc. requires the development of new products and applications of engineering, and the successful management of clinical trials and related extraneous and domestic regulatory processes; (2) costs or difficulties relating to the integration of the businesses of Brookwood Pharmaceuticals and BioFX Laboratories with SurModics' business organisation may be greater than expected and may adversely affect the company's results of operations and financial condition; (3) developments in the regulative environment, as well as market and economic conditions, and our reliance on third parties, may adversely affect our business trading operations and gainfulness, and the company's ability to reach our fiscal 2008 incorporated goals and to realise the voltage of our pipeline; and (4) former factors identified under "Risk Factors" in Part I, Item 1A of our Annual Report on Form 10-K for the financial year concluded September 30, 2007, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our web site at hypertext transfer protocol://www.surmodics.com and at the SEC web site at hypertext transfer protocol://www.securities and Exchange Commission.gov. Forward-looking statements talk only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.
SurModics, Inc.
More info
Wednesday, 6 August 2008
Hey, Jonas Brothers Fans: The Jersey Boys' 3-D Flick Has A Release Date!
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Jonas Brothers 3-D Concert Flick Gets A Release Date
Published by Brian Jacks on Friday, August 1, 2008 at 2:14 pm.
You�ve been bombarding TRL, spamming our web site and screaming on FNMTV. Now you�ll be capable to get up, shut and personal with the Jersey boys themselves. According to Variety, the Jonas Brothers� previously announced 3-D concert moving-picture show has snagged a release date: February 27, 2009.
The currently ungentle Disney flick will come after the mold of the recent Miley Cyrus smash hit, combining live concert footage with behind-the-scenes moments. Not much else is known about the flick yet, simply stay tuned to the MTV Movies Blog for all your breaking Jonas Brothers picture needs.
So how excited are you guys to see the Jonas Brothers in glorious 3-D? Are you already clearing your schedules to see it possibility day? Chime in below!
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Thursday, 26 June 2008
Nude challenge in Big Brother house
New housemate Stuart has set pulses racing yet again in the 'Big Brother' house with the latest task.
Having flirted with both Sylvia and Jennifer, the 25-year-old was called to the Diary Room to find out about the challenge.
On returning he told the group: "Housemates must use their imagination and creativity as they take part in Big Brother's Life Class. Housemates must either paint or sculpt the new housemate, Stuart, in the nude."
Asked to explain her work, Sylvia said: "This is my sexy interpretation of Stu. I have focused on his sexy body with his beautiful pecs going on, his nice eyes and I think his face is really pretty."
But Stuart picked Jennifer - who said her painting was a reference to Adonis - as the winner.
There was further disappointment for Sylvia last night when Stuart appeared to play down the prospects of a relationship between them.
After talking to Stuart, Jennifer told Sylvia: "He's not saying that he doesn't find you attractive, and that he doesn't think things could develop in here. He's just saying that at such an early stage, after two days... he doesn't want to start anything and isolate himself from the group."
Having flirted with both Sylvia and Jennifer, the 25-year-old was called to the Diary Room to find out about the challenge.
On returning he told the group: "Housemates must use their imagination and creativity as they take part in Big Brother's Life Class. Housemates must either paint or sculpt the new housemate, Stuart, in the nude."
Asked to explain her work, Sylvia said: "This is my sexy interpretation of Stu. I have focused on his sexy body with his beautiful pecs going on, his nice eyes and I think his face is really pretty."
But Stuart picked Jennifer - who said her painting was a reference to Adonis - as the winner.
There was further disappointment for Sylvia last night when Stuart appeared to play down the prospects of a relationship between them.
After talking to Stuart, Jennifer told Sylvia: "He's not saying that he doesn't find you attractive, and that he doesn't think things could develop in here. He's just saying that at such an early stage, after two days... he doesn't want to start anything and isolate himself from the group."
Wednesday, 18 June 2008
Razorlight - Borrell Movie Stalled
RAZORLIGHT frontman JOHNNY BORRELL's acting career has been thrown into question - after production on his debut movie THE MEAT TRADE has stalled.
The British rocker was reportedly set to play a musician killed by two grave robbers - played by Colin Firth and Robert Carlyle - in novelist Irvine Welsh's latest screenplay, originally slated for release later this year (08).
But Borrell's big screen debut appears to still be some way off - the singer has revealed the project is still waiting for the green light.
He says, "It's still not certain yet. We'll just have to wait and see. But I'm really hoping that it does happen because I've read the script and it's brilliant - I get offers to act all the time, but this is the first one I've ever wanted to do."
See Also
Monday, 9 June 2008
Operator Please - Operator Please Keyboardist Quits
Australian rockers OPERATOR PLEASE have parted ways with their keyboardist SARAH GARDINER.
The band insist the split was mutual following Gardiner's two-month break from touring with the group.
Gardiner aired her intentions to leave Operator Please shortly after filming the video for their forthcoming single Two For My Seconds.
In a posting on social networking site Facebook, Gardiner writes, "The video features myself truly playing the piano on a busy street in Sydney - an oddly appropriate send off!"
Operator Please are currently auditioning replacements for their upcoming European tour, which kicks off in London on 18 April (08).
See Also
Tuesday, 3 June 2008
Corrie star Haworth expecting first child
'Coronation Street' star Julia Haworth has revealed that she is pregnant with her first child.
The actress, who plays Claire Peacock in the soap, is due to give birth in July.
The actress revealed she found out the news in November but wanted to keep it quiet until her 12 week scan.
She told The Mirror newspaper: "We haven't stopped smiling. It's such a special time and I feel so lucky we're going to share it."
Haworth added that her character's postnatal depression following the birth of son Freddie had helped "prepare" her for being a mother.
The 28-year-old married accountant Jon Wormold in May 2006 after a two-year romance.
The actress, who plays Claire Peacock in the soap, is due to give birth in July.
The actress revealed she found out the news in November but wanted to keep it quiet until her 12 week scan.
She told The Mirror newspaper: "We haven't stopped smiling. It's such a special time and I feel so lucky we're going to share it."
Haworth added that her character's postnatal depression following the birth of son Freddie had helped "prepare" her for being a mother.
The 28-year-old married accountant Jon Wormold in May 2006 after a two-year romance.
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